TCDD blocks androgen-dependent cell proliferation of LNCaP cells through modulation of RB phosphorylation
نویسندگان
چکیده
217 words. Introduction: 790 words. Discussion: 1,240 words. Abreviations : AHR: Aryl hydrocarbon receptor; AhRE: Ah receptor response element (also named XRE, for xenobiotic, and DRE, for dioxin response element); AR: Androgen receptor; ARE: Androgen receptor response element; ARNT: Aryl hydrocarbon receptor nuclear translocator; bHLH: basic region-helix-loop-helix; CDT: Charcoal-dextran treated FBS; DHFR: Dihydrofolate reductase; DHT: Dihydrotestosterone; ER: Estrogen receptor; FBS: Fetal bovine serum; HSP: Heat-shock protein; IMEM: Improved minimal essential médium; LNCaP: Lymph Node Cancer of the Prostate; NQO-1: NAD(P)H-dependent quinone oxidoreductase-1; PAS: PER-ARNT-SIM; PSA: Prostate-specific antigen; RB: Retinoblastoma; TCDD: 2,3,7,8-tetrachlorodibenzo-p-dioxin. This article has not been copyedited and formatted. The final version may differ from this version. Molecular Pharmacology Fast Forward. Published on May 26, 2004 as DOI: 10.1124/mol.104.000356 at A PE T Jornals on O cber 9, 2017 m oharm .aspeurnals.org D ow nladed from
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Effects of Antiproliferative Protein (APP) on Modulation of Cytosolic Protein Phosphorylation of Prostatic Carcinoma Cell Line LNCaP
Antiproliferative protein (APP) isolated from conditioned media of two androgen-independent prostatic carcinoma cell lines, PC3 and Du-145 was shown to inhibit selectively cell proliferation of androgen-dependent prostate cancer cell line LNCaP in a dose dependent manner. This protein was further purified with HPLC using hydrophobic interaction column (phenyl 5PW) and was used to study the modu...
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